Anita Blake (from Kiriel's copy of The First Death Pt. 1 comic)
I first discovered Laurell K. Hamilton when I had a subscription to a sci-fi and fantasy book club. They had a compendium of the first three Anita Blake, Vampire Hunter novels. I bought it on the recommendation of an ex-boyfriend who had already read them and I loved it. Anita is the perfect combination of sarcastic wit and kick-ass fighting. Granted, she has a lot of personal issues (who am I kidding, the girl has subscriptions), but I love her anyway.
Who's your favorite female character? Is the book part of a series or a stand-alone novel?